Package: RAS 1.0.3
Jiahe Jin
RAS: Regional Association Score for Genome-Wide Association Studies
Implements the Regional Association Score (RAS) method for genome-wide association studies (GWAS). For each single nucleotide polymorphism (SNP), RAS quantifies the strength of association within its surrounding genomic region, arranges these regional scores along the chromosome into a signal profile, and applies changepoint detection to locate association regions, improving statistical power while controlling the false positive rate. The method is described in Jiang and Zhang (2025) <doi:10.1073/pnas.2419721122>.
Authors:
RAS_1.0.3.tar.gz
RAS_1.0.3.zip(r-4.7-x86_64)RAS_1.0.3.zip(r-4.7-arm64)RAS_1.0.3.zip(r-4.6-x86_64)RAS_1.0.3.zip(r-4.6-arm64)RAS_1.0.3.zip(r-4.5-x86_64)
RAS_1.0.3.tgz(r-4.6-x86_64)RAS_1.0.3.tgz(r-4.6-arm64)RAS_1.0.3.tgz(r-4.5-x86_64)RAS_1.0.3.tgz(r-4.5-arm64)
RAS_1.0.3.tar.gz(r-4.7-arm64)RAS_1.0.3.tar.gz(r-4.7-x86_64)RAS_1.0.3.tar.gz(r-4.6-arm64)RAS_1.0.3.tar.gz(r-4.6-x86_64)
RAS_1.0.3.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
RAS/json (API)
| # Install 'RAS' in R: |
| install.packages('RAS', repos = c('https://hepingzhangyale.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/hepingzhangyale/ras/issues
Last updated from:24fc8f2115. Checks:15 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-arm64 | OK | 113 | ||
| linux-devel-x86_64 | OK | 126 | ||
| source / vignettes | OK | 167 | ||
| linux-release-arm64 | OK | 99 | ||
| linux-release-x86_64 | OK | 115 | ||
| macos-release-arm64 | OK | 141 | ||
| macos-release-x86_64 | OK | 247 | ||
| macos-oldrel-arm64 | OK | 164 | ||
| macos-oldrel-x86_64 | OK | 205 | ||
| windows-devel-arm64 | OK | 326 | ||
| windows-devel-x86_64 | OK | 105 | ||
| windows-release-arm64 | OK | 316 | ||
| windows-release-x86_64 | OK | 71 | ||
| windows-oldrel-x86_64 | OK | 80 | ||
| wasm-release | OK | 102 |
Exports:compute_gwas_weightscompute_pgs_matrixget_break_pointsget_local_maximumrasras_detectras_memoryras_scanras_validaterelease_memoryscreen_forward_max_regionslope_test
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| RAS: Regional Association Score for Genome-Wide Association Studies | RAS-package RAS |
| Compute Per-SNP GWAS Effect Size Weights | compute_gwas_weights |
| Build the Per-Individual PGS Contribution Matrix | compute_pgs_matrix |
| Detect a Single Changepoint via Segmented Regression | get_break_points |
| Find the Local Maximum Within a Window | get_local_maximum |
| Plot a RAS Result Object | plot.ras |
| Print a RAS Result Object | print.ras |
| RAS: Regional Association Score Analysis | ras |
| First-Pass Changepoint Detection via Sliding Window | ras_detect |
| Estimate Memory Requirements and Check System Readiness | ras_memory |
| Run the RAS Scan (Repetition Screening Loop) | ras_scan |
| Second-Pass Changepoint Validation | ras_validate |
| Release Memory Back to the OS | release_memory |
| Forward Scan to Compute the RAS Profile | screen_forward_max_region |
| One-Tailed Slope Test Through the Origin | slope_test |